The diagnosis of chikungunya remains a challenge because of its non-specific clinical manifestations.6
Some symptoms such as headache,nausea, fatigue and rash overlap with other infections.6
However, some symptoms can prompt suspicion of chikungunya and facilitate diagnosis, such as joint swelling and muscle pain.10
The disease also shares common symptoms with malaria, typhoid and dengue.11
The differential diagnosis of chikungunya varies based on place of residence, travel history and exposures.12
In settings of chikungunya co-transmission with other mosquito-borne diseases, such as dengue and zika, a presumptive diagnosis of chikungunya was
correct in
ONLY 10 TO 40%
OF CASES.13
The diagnosis of chikungunya cannot be confirmed based solely on clinical findings. Similar to other arboviruses, confirmed diagnosis of chikungunya is obtained through molecular and/or serological methods.13
DIAGNOSTIC APPROACH13
SUSPECT IF…
Acute onset of fever >38oC
Severe arthralgia or arthritis not explained by other medical conditions
Resident of or visitor to endemic areas within two weeks prior to onset of symptoms
CONFIRM WHEN…
Suspected case AND
Positive result in any specific CHIKV test (viral isolation, molecular assay, anti-CHIKV IgM, seroconversion or 4-fold rise in anti-CHIKV antibodies between acute and convalescent samples)
Adapted from Natrajan et al. (2019)
Learn more about who may be at risk of chikungunya.